Metabolism Resmetirom is metabolized by CYP2C8 and isn't metabolized by other CYP enzymes in vitro. MGL-3623 is An important metabolite having a 28-occasions reduced potency for THR-? than resmetirom.Sickness-Affiliated Maternal and/or Embryo/Fetal Hazard You'll find threats to your mom and fetus connected with fundamental maternal NASH with liver